Price attracted national attention in the mid-1970s during his three-year collaboration with blues guitarist Roy Buchanan. The pair toured the U.S. and Canada, playing Carnegie Hall in New York, the Newport Jazz Festival, the Roxy and Troubadour in Los Angeles, and the Spectrum in Philadelphia. After leaving Buchanan, Price formed the Keystone Rhythm Band, which toured the Eastern US on a circuit that stretched from Boston to Atlanta with large followings in Boston, Philadelphia, Washington, DC and North Carolina. Sustaining several personnel changes, the band performed until 1990. He then formed The Billy Price Band, which currently consists of Steve Delach (guitar), Paul Thompson (bass), Dave Dodd (drums), Jimmy Britton (keyboards), Joe Herndon (trumpet), Eric DeFade (tenor sax) and Rick Matt (baritone and tenor sax).
Though he works full-time in corporate communications at the Software Engineering Institute at Carnegie Mellon University, he continues to perform regularly in Pittsburgh, the eastern United States, and occasionally in Europe.